The IL6R Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD126, gp80, IL-6R, IL-6Ralpha, IL6R, IL6R1, IL6RA, and Interleukin 6 Receptor. This antibody recognizes Human antigen. The IL6R Polyclonal Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine